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KMID : 0603820080140030157
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Journal of Experimental & Biomedical Science
2008 Volume.14 No. 3 p.157 ~ p.165
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Analysis of the bcl-2, Ki-67 and p53 Expression Level Based on the Gleason Score Group of Prostate Adenocarcinoma
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Kim Tai-Jeon
Kim Sung-Chul
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Abstract
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Recently, the number of patients with prostate cancer has been increased gradually by both the change of living environment and the increase of aged population. In this study the serum prostate specific antigen (PSA) level was compared to the Gleason score known as a prognostic factor for the prostate cancer. In the Gleason score 6 and 9~10, the average age was 69.68 years old and 69.52 years old, respectively and there was no statistically difference in both of age and Gleason score. the PSA serum consistency appeared ＜4 ng/mL as example 1, 4~20 ng/mL as example 17 and ≥20 ng/mL as example 4 in the Gleason score 6, and In the Gleason score 9~10, it appeared ＜4 ng/mL as example 1, 4~20 ng/mL as example 6 and ≥20 ng/mL as example 15. PSA serum consistency in the Gleason score 9~10 showed higher value than those of Gleason score 6 (P＜0.05). Next, expression ratios of bcl-2, Ki-67 and p53 were examined in the Gleason score 6 and 9~10. the p53 expression ratio, a tumor suppression gene, appeared the significance statistically by the classification of the Gleason score as example 7 (28%) in the Gleason score 6 and as example 16 (64%) in the Gleason score 9~10 (P＜0.05). but not different in the expression ratios of the Ki-67 and bcl-2. The expression ratio of p53 by the expression ratio of bcl-2 and the expression ratio of Ki-67 by the expression ratio of p53 had a positive relationship in all of the Gleason score 6 and the Gleason score 9~10 (P＜0.05). However, the expression ratio of Ki-67 by the expression ratio of bcl-2 did not show any significance in the Gleason score 9~10 (P＜0.05). Therefore, the results suggested that p53 expression could be used as an independent prognostic factor.
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KEYWORD
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Prostate cancer, bcl-2, Ki-67, p53 Gleason score, Prognostic factor
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